Covalent organic frameworks: spotlight on applications in the pharmaceutical arena
Pushpa Pilli1, Hema Sree Kommalapati1, Vijaya Madhyanapu Golla1
1Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 500037, India.
Bioanalysis
|March 6, 2024
Summary
Covalent organic frameworks (COFs) offer tunable properties for advanced analytical separations. This review highlights COF synthesis and applications in membranes, solid-phase extraction, and chiral separations.
Area of Science:
- Materials Science
- Analytical Chemistry
- Chemical Engineering
Background:
- Covalent organic frameworks (COFs) possess unique properties like tunable structures, high surface areas, and permanent porosity.
- These characteristics make COFs highly promising for various separation and analytical applications.
Purpose of the Study:
- To provide a historical overview of COF synthesis and applications.
- To explore the potential of COFs in diverse fields, including analytical separation research.
- To highlight advancements in COF synthesis for chiral and isomeric compound separation.
Main Methods:
- Review of existing literature on COF synthesis and applications.
- Discussion of COF-based membranes for gas separation and water treatment.
- Exploration of COFs as sorbents in solid-phase extraction and solid-phase microextraction.
Main Results:
- COFs are versatile materials with demonstrated utility in gas separation, water purification (desalination, heavy metal, and dye removal), membrane filtration, sensing, and fuel cells.
- COFs show significant promise as effective sorbents for solid-phase extraction and coatings for solid-phase microextraction.
- Recent advancements focus on synthesizing COFs for the challenging separation of chiral and isomeric compounds.
Conclusions:
- COFs represent a rapidly evolving class of materials with broad applicability in analytical separation science.
- Further research into COF synthesis and application development will unlock their full potential in various technological domains.
- The unique properties of COFs position them as key materials for future innovations in separation technologies and chiral analysis.
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