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Enhancing Adhesion of Fibrin-Based Hydrogel to Polythioether Polymer Surfaces.

Miriam Aischa Al Enezy-Ulbrich1,2, Klaus Kreuels3, Marc Simonis1,2

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Summary

Researchers enhanced the adhesion of fibrin hydrogels to polythioether scaffolds for tissue engineering. Using functional copolymers significantly boosted bonding strength, paving the way for advanced (bio)hybrid constructs.

Keywords:
adhesionbiohybrid materialfibrinhydrogelpolythioetherthiol−ene

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Developing stable (bio)hybrid constructs for tissue engineering requires robust adhesion between scaffolds and biomatrices.
  • Polythioether-based polymers, fabricated via thiol-ene click chemistry, are promising for 3D printing scaffolds.
  • Fibrin hydrogels are widely used biomatrices but often exhibit limited adhesion to synthetic polymers.

Purpose of the Study:

  • To investigate and enhance the adhesion of fibrin-based hydrogels to polythioether polymer surfaces.
  • To evaluate the effectiveness of poly(N-vinylpyrrolidone-co-glycidyl methacrylate) (PVP-co-GMA) copolymers in improving fibrin-polymer bonding.
  • To optimize methods for characterizing adhesion strength in fibrin-polythioether systems.

Main Methods:

  • Fabrication of polythioether scaffolds using thiol-ene click chemistry.
  • Characterization of fibrin hydrogel adhesion to polythioether surfaces via single-lap tensile shear testing.
  • Application of linear functional PVP-co-GMA copolymers to improve interfacial bonding.

Main Results:

  • Substantial intrinsic adhesion between fibrin hydrogel and polythioether was observed (4.9 ± 1.0 kPa).
  • Incorporation of PVP-co-GMA copolymers significantly increased adhesion strength to 18.4 ± 3.4 kPa.
  • PVP-co-GMA copolymers also showed strong covalent binding to polythioether (32.2 ± 2.7 kPa), enhancing overall construct stability.

Conclusions:

  • Functional copolymers like PVP-co-GMA can dramatically improve fibrin hydrogel adhesion to polythioether scaffolds.
  • Optimized interfacial bonding is crucial for creating stable (bio)hybrid constructs in tissue engineering.
  • The findings provide a pathway for developing advanced 3D-printed scaffolds with enhanced biomatrix integration.