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Deep Eutectic Solvent Eutectogels for Delivery of Broad-Spectrum Antimicrobials
Z L Shaw1, Miyah N Awad2, Soroosh Gharehgozlo2
1School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
ACS Applied Bio Materials
|March 6, 2024
Summary
New eutogels, a type of deep eutectic solvent (DES) gel, show significant antimicrobial properties. These advanced wound dressings effectively reduce bacterial and fungal infections, offering a promising alternative to traditional hydrogels.
Area of Science:
- Materials Science
- Biotechnology
- Infectious Diseases
Background:
- Gel-based wound dressings are crucial for managing infections.
- Deep eutectic solvents (DESs) offer tunable, non-volatile alternatives to hydrogels.
- Eutogels can solubilize a wide range of therapeutic agents.
Purpose of the Study:
- To develop and evaluate a novel eutogels wound dressing.
- To incorporate multiple antimicrobial agents into the eutogels formulation.
- To assess the efficacy of the eutogels against key bacterial and fungal pathogens.
Main Methods:
- Formulation of a choline chloride:glycerol-cellulose eutogels.
- Loading of antimicrobial agents: silver nanoparticles, black phosphorus nanoflakes, octenidine dihydrochloride, tetracycline hydrochloride, and fluconazole.
- In vitro testing of antimicrobial efficacy against *Staphylococcus aureus*, *Pseudomonas aeruginosa*, and *Candida albicans*.
Main Results:
- The developed eutogels demonstrated significant antimicrobial activity.
- Achieved >97% growth reduction against methicillin-resistant *Staphylococcus aureus* (MRSA).
- Demonstrated >97% growth reduction against *Pseudomonas aeruginosa* and *Candida albicans*.
Conclusions:
- Choline chloride:glycerol-cellulose eutogels loaded with multiple antimicrobials are effective against major pathogens.
- These eutogels represent a promising advanced wound care technology.
- The formulation shows potential for preventing and treating bacterial and fungal wound infections.
