Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

5.1K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.1K
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

242
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
242
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

114
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
114

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum: Measured and Monte Carlo simulated electron backscatter to the monitor chamber for the varian TrueBeam linac (2016<i>Phys. Med. Biol</i>.<b>61</b>8779).

Physics in medicine and biology·2026
Same author

A pilot study: dual-contrast arthrography using photon-counting detector computed tomography with gadolinium and iodine contrasts.

Physics in medicine and biology·2026
Same author

Gold Nanoparticle Radiosensitization for High-Dose-Rate Brachytherapy: Differential Efficacy of PEG- and RGD-Functionalized Gold Nanoparticles Across 2-Dimensional, 3-Dimensional, and in vivo Prostate Cancer Models.

International journal of nanomedicine·2026
Same author

Metabolomic properties of the fluid from the surgical ligation after breast-conserving therapy and intraoperative radiotherapy.

Scientific reports·2026
Same author

Using Artificial Intelligence to Enhance Evidence Search and Synthesis.

The American journal of nursing·2026
Same author

1H spin-lattice relaxation enhancement caused by magnetic core-shell nanoparticles-Testing theoretical models.

The Journal of chemical physics·2026

Related Experiment Video

Updated: Jul 1, 2025

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

9.9K

X-ray-Sensitive Doped CaF2-Based MRI Contrast Agents for Local Radiation Dose Measurement.

Adriaan L Frencken1,2, Devon Richtsmeier2,3, R Lee Leonard4

  • 1Department of Chemistry, University of Victoria, Victoria, British Columbia V8W 2Y2, Canada.

ACS Applied Materials & Interfaces
|March 6, 2024
PubMed
Summary

This study introduces novel MRI contrast agents for precise internal radiation dose measurement in liquids, paving the way for safer medical imaging and radiation therapy applications.

Keywords:
cancer treatmentcontrast agentsdosimetrymagnetic resonance imagingmedical imagingnanofabricationnanoparticles

More Related Videos

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
06:24

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

15.1K
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.0K

Related Experiment Videos

Last Updated: Jul 1, 2025

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

9.9K
Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
06:24

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

15.1K
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.0K

Area of Science:

  • Medical Physics
  • Nanotechnology
  • Radiochemistry

Background:

  • Ionizing radiation is crucial in medical diagnostics (CT) and treatments (RT), but accurate dose measurement is vital to prevent healthy tissue damage.
  • Current methods rely on theoretical predictions or external measurements, limiting precision for techniques like MRI-guided RT.
  • Precise internal radiation dose measurement is needed to enhance the safety and efficacy of radiation-based medical procedures.

Purpose of the Study:

  • To develop a novel method for measuring internal radiation dose in liquids for potential in vivo applications.
  • To utilize MRI contrast agents (CAs) that exhibit dose-sensitive signal changes.
  • To demonstrate the efficacy of specific nanoparticles as MRI-based radiation dose sensors.

Main Methods:

  • Developed citrate-capped calcium fluoride (CaF2) nanoparticles doped with Eu3+ or Fe2+/Fe3+ ions.
  • Investigated the dose-dependent signal changes in MRI using these nanoparticles.
  • Assessed the impact of ionizing radiation on the magnetic properties of the doped nanoparticles.

Main Results:

  • Eu3+-doped CaF2 nanoparticles showed a significant increase in proton relaxation rates at 40 kV, indicating dose sensitivity.
  • Fe2+/Fe3+-doped CaF2 nanoparticles exhibited a notable increase in proton relaxation rates at 6 MV after irradiation.
  • The observed changes in MRI contrast correlate with the generated free electrons and oxidative species from ionizing radiation.

Conclusions:

  • The developed CaF2 nanoparticles serve as effective MRI contrast agents for measuring ionizing radiation dose in liquids.
  • This approach holds significant promise for accurate in vivo local radiation dose assessment in clinical settings.
  • Intravenous injection of these CAs in saline solution could enable real-time internal dosimetry during MRI-guided radiation therapy.