Highlights on Fluorine-containing Drugs Approved by U.S. FDA in 2023

Area of Science:

• Medicinal Chemistry
• Drug Discovery
• Pharmacology

Background:

• Fluorine incorporation is a key strategy in modern drug discovery.
• The U.S. Food and Drug Administration (FDA) approved 55 new drugs in 2023.
• A significant portion of these approvals involved fluorinated compounds, highlighting their therapeutic importance.

Purpose of the Study:

• To review the 12 fluorinated drugs approved by the FDA in 2023.
• To detail the discovery, composition, and therapeutic applications of these new fluorinated medicines.
• To discuss emerging trends in fluorinated drug development.

Main Methods:

• Literature review of FDA-approved drugs in 2023.
• Analysis of drug composition, approval dates, and sponsors.
• Compilation of information on indications and mechanisms of action for fluorinated drugs.

Main Results:

• Twelve new fluorine-containing drugs were approved by the FDA in 2023.
• Details provided for each drug including brand name, sponsor, and therapeutic indication.
• Mechanisms of action for these novel fluorinated therapeutics are outlined.

Conclusions:

• Fluorinated drugs represent a substantial and growing segment of new pharmaceutical approvals.
• The review provides a valuable resource for researchers in drug discovery and medicinal chemistry.
• Future trends suggest continued innovation and application of fluorine in developing new medicines.