Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Author Correction: Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation.

Nature communications·2024

Same author

Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation.

Nature communications·2024

Same author

The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes.

The New England journal of medicine·2001

Same author

Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectoris. OPUS-TIMI 16 Investigators.

The American journal of cardiology·2001

Same author

Developing a bereavement program in a university hospital setting.

Oncology nursing forum·1988

Same journal

The Role of Digital Health Technologies in Early Detection and Management of Alzheimer's Disease.

Current Alzheimer research·2026

Same journal

Quantifying Short-Term Functional Changes After Lecanemab Treatment in Early Alzheimer's Disease: An Exploratory 3-Month Follow-Up Case Report Using Eye Movement and Gait Analysis.

Current Alzheimer research·2026

Same journal

Corrigendum to: Advancing Alzheimer's Disease Diagnosis Using VGG19 and XGBoost: A Neuroimaging-Based Method.

Current Alzheimer research·2026

Same journal

Corrigendum to: Lithium Chloride Improves Electrophysiological and Memory Deficits in Rats with Streptozotocin-Induced Alzheimer's Disease.

Current Alzheimer research·2026

Same journal

Apolipoprotein E Mimetics in Targeted Drug Delivery: Advances and Therapeutic Potential for Neurodegenerative and Cardiovascular Diseases.

Current Alzheimer research·2026

Same journal

Association of Polymorphisms in Genes Involved in Serotonergic Signaling with the Risk of Developing Alzheimer's Disease.

Current Alzheimer research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 1, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Multimodal Gamma Stimulation Improves Activity but not Memory in Aged Tgf344-AD Rats.

J H Bentley¹, J I Broussard¹

¹Department of Neurobiology and Anatomy, University of Texas McGovern Medical School, Houston, TX 77030, USA.

Current Alzheimer Research

|March 6, 2024

Summary

This summary is machine-generated.

Multimodal gamma stimulation did not improve memory in Alzheimer's rats, but increased exploratory activity. Further research is needed to understand these mixed results in Alzheimer's disease (AD) models.

Keywords:

Alzheimer’s disease.Neuromodulation gamma memory object location task spontaneous alternation dementia

More Related Videos

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Published on: June 22, 2015

Author Spotlight: Exploring Acupuncture in Alzheimer's Research from Thread-Embedding Techniques to Clinical Trials

Author Spotlight: Exploring Acupuncture in Alzheimer's Research from Thread-Embedding Techniques to Clinical Trials

Published on: May 10, 2024

Related Experiment Videos

Last Updated: Jul 1, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Published on: June 22, 2015

Author Spotlight: Exploring Acupuncture in Alzheimer's Research from Thread-Embedding Techniques to Clinical Trials

Author Spotlight: Exploring Acupuncture in Alzheimer's Research from Thread-Embedding Techniques to Clinical Trials

Published on: May 10, 2024

Area of Science:

Neuroscience
Biomedical Engineering

Background:

Alzheimer's disease (AD) research explores multimodal sensory gamma stimulation.
Transgenic mouse models show promise, but rats offer closer human evolutionary relevance.
The TgF344-AD rat model exhibits key AD hallmarks like hyperphosphorylated tau and neuronal loss.

Purpose of the Study:

To evaluate multimodal gamma stimulation's efficacy in the TgF344-AD rat model.
To assess the impact on memory using object location and spontaneous alternation tasks.

Main Methods:

A low-cost, Arduino-based multimodal gamma stimulator was designed and built.
TgF344-AD rats received simultaneous light and auditory gamma stimulation.
Cognitive performance was measured using Novel Object Location (NOL) and spontaneous alternation tasks before and after treatment.

Main Results:

Multimodal gamma stimulation did not enhance memory performance in either task.
Gamma-stimulated rats showed increased exploration time in the NOL task.
Spontaneous alternation task revealed greater exploratory activity in the stimulated group.

Conclusions:

Multimodal gamma stimulation did not improve memory in TgF344-AD rats.
Increased exploratory activity suggests a potential, though not memory-enhancing, effect.
Limitations include potential aging effects, model differences, and light cycle influences.