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Updated: Jul 1, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

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Expression of concern: Different apoptosis modalities in periprosthetic membranes

    Journal of Biomedical Materials Research. Part A
    |March 6, 2024
    PubMed

    Insights

    Concerns were raised regarding histological image irregularities in a study on periprosthetic membranes. Image analysis confirmed high similarities, impacting the integrity and conclusions of the research.

    Area of Science:

    • Biomedical Materials Science
    • Cell Biology
    • Histopathology

    Context:

    • Periprosthetic membranes are associated with implant complications.
    • Understanding cellular behavior within these membranes is crucial for improving implant outcomes.
    • Apoptosis, or programmed cell death, plays a role in tissue response to implants.

    Purpose:

    • To investigate and characterize the different modalities of apoptosis occurring in periprosthetic membranes.
    • To analyze the histological features and cellular events related to cell death in these tissues.

    Summary:

    • This study examined apoptosis in periprosthetic membranes.
    • Irregularities were identified in histological images (Figure 1A and 1B), showing high similarities between different membranes.
    • Professional image analysis confirmed these similarities, raising concerns about data integrity.

    Impact:

    • The identified image irregularities affect the integrity of the presented micrographs.
    • The journal issued an Expression of Concern due to these issues.
    • The investigation could not exclude that these concerns impact the overall conclusions of the article.

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