Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

315
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
315
Human Genetics01:28

Human Genetics

566
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
566
Genetic Lingo01:11

Genetic Lingo

102.7K
Overview
102.7K
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Cancer Prevention02:59

Cancer Prevention

6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.2K
Polygenic Traits01:18

Polygenic Traits

65.8K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
65.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent Progress in Mechanism-Based Therapies for <i>GJB2</i>-Related Hearing Loss.

International journal of molecular sciences·2026
Same author

Association of outdoor light exposure with bone mineral density and osteoporosis risk: A gene-environment interaction analysis.

Bone·2026
Same author

A precision therapy paradigm for noise-induced hearing loss: integrating transcriptome-guided drug repurposing with <i>in situ</i> hydrogel delivery.

Biomaterials science·2026
Same author

The Current Situation and Development of Endoscopic Ear Surgery in China.

World journal of otorhinolaryngology - head and neck surgery·2026
Same author

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Hearing Loss in Infants and Children with Asymptomatic Congenital Cytomegalovirus Infection: An Update in Diagnosis, Screening and Treatment.

Diagnostics (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jul 1, 2025

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:15

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

473

Greenness, Genetic Predisposition, and Tinnitus.

Lan-Lai Yuan1, Dan-Kang Li2,3, Yao-Hua Tian2,3

  • 1Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|March 6, 2024
PubMed
Summary

Living in greener areas is linked to a lower risk of tinnitus. This study found that residential greenness, measured by NDVI, significantly reduces tinnitus odds, especially when interacting with genetic predisposition.

Keywords:
UK biobankgenetic predispositionresidential greennesstinnitus

More Related Videos

A Low Cost Setup for Behavioral Audiometry in Rodents
09:23

A Low Cost Setup for Behavioral Audiometry in Rodents

Published on: October 16, 2012

12.7K
A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
07:05

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

11.0K

Related Experiment Videos

Last Updated: Jul 1, 2025

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:15

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

473
A Low Cost Setup for Behavioral Audiometry in Rodents
09:23

A Low Cost Setup for Behavioral Audiometry in Rodents

Published on: October 16, 2012

12.7K
A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
07:05

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

11.0K

Area of Science:

  • Environmental Health
  • Epidemiology
  • Genetics

Background:

  • Tinnitus is a prevalent condition with multifactorial causes.
  • Environmental factors, such as residential greenness, are increasingly recognized for their impact on health.
  • The interplay between environmental exposures and genetic susceptibility in tinnitus development requires further investigation.

Purpose of the Study:

  • To examine the association between residential greenness and tinnitus.
  • To investigate the potential interaction between residential greenness and genetic predisposition to tinnitus.

Main Methods:

  • Utilized the normalized difference vegetation index (NDVI) to quantify residential greenness.
  • Employed logistic regression for cross-sectional analysis and Cox proportional hazard models for longitudinal analysis within the UK Biobank cohort.
  • Defined tinnitus based on self-reported data.

Main Results:

  • Higher residential greenness was associated with significantly lower odds of tinnitus in cross-sectional analysis (OR 0.97, 95% CI: 0.95 to 0.99).
  • Longitudinal analysis revealed a similar inverse association between NDVI and incident tinnitus (HR 0.92, 95% CI: 0.86 to 0.98).
  • A significant interaction (P < 0.05) was identified between residential greenness and genetic predisposition to tinnitus.

Conclusions:

  • Residential greenness demonstrates a protective association with tinnitus.
  • The findings highlight a significant interaction effect, suggesting that greenness may modulate tinnitus risk in genetically susceptible individuals.