Body composition measurements and clinical outcomes in patients with resectable pancreatic adenocarcinoma - analysis...

Area of Science:

• Oncology
• Radiology
• Body Composition Analysis

Background:

• Sarcopenic obesity and muscle attenuation are linked to survival in advanced pancreatic ductal adenocarcinoma (PDA).
• These associations are not well-established for patients with resectable PDA.
• This study investigates body composition metrics in resectable PDA.

Purpose of the Study:

• To examine the association between skeletal muscle and adipose tissue (measured by CT) and overall survival (OS) in patients with resectable PDA.
• To analyze body composition parameters in a prospective multicenter trial for resectable PDA.
• To determine if sarcopenia or sarcopenic obesity affects survival in this patient group.

Main Methods:

• Secondary analysis of the S1505 clinical trial (NCT02562716) involving patients with resectable PDA.
• Baseline CT images at L3 level analyzed for skeletal muscle and adipose tissue metrics (area and density).
• Cox regression models used to analyze relationships between CT metrics and OS, adjusted for baseline characteristics.

Main Results:

• 90 evaluable cases from 98 eligible participants.
• Sarcopenia present in 35.9%, sarcopenic obesity in 11.2%.
• Visceral adipose tissue area (VATA) was significantly associated with improved OS (HR, 1.58; P = .05). No significant association found between OS and sarcopenia or sarcopenic obesity.

Conclusions:

• Visceral adipose tissue is associated with survival in resectable PDA patients receiving perioperative chemotherapy.
• Sarcopenia and sarcopenic obesity were not associated with overall survival in this cohort.
• Further research is needed to explore these body composition findings in resectable PDA.