Achieving Biomedically Desirable Nitric Oxide Release from Glucose Monitor Surfaces Via a Cu-Based Catalyst Coating

Area of Science:

• Biomedical Engineering
• Materials Science
• Analytical Chemistry

Background:

• Accurate glucose monitoring is crucial for diabetes management.
• Nitric oxide (NO) plays a role in physiological processes and can influence sensor performance.
• Metal-organic frameworks (MOFs) offer tunable properties for material integration.

Purpose of the Study:

• To design and evaluate a novel blood-contacting glucose monitor incorporating a nitric oxide (NO)-releasing MOF.
• To assess the impact of MOF integration and NO release on glucose sensor performance.
• To investigate the potential of NO to modulate endogenous NO donors for enhanced sensing.

Main Methods:

• Fabrication of a glucose sensor with an embedded NO-releasing MOF in the outer polymer layer.
• Amperometric testing of the sensor across various glucose concentrations.
• Evaluation of sensor performance metrics including regression fit, dynamic range, and reproducibility in the presence of an NO donor (S-nitrosoglutathione).

Main Results:

• The developed glucose monitor successfully integrated a nitric oxide (NO)-releasing MOF.
• While signal response was slightly diminished, the sensor maintained excellent linearity (R² = 0.9944).
• The sensor demonstrated comparable dynamic range and reproducibility even with the presence of NO and S-nitrosoglutathione.

Conclusions:

• The integration of NO-releasing MOFs into glucose sensors is feasible.
• The modified sensors exhibit robust performance characteristics suitable for glucose monitoring.
• This approach offers a potential strategy for developing advanced glucose monitoring devices with modulated NO release.