Investigating the Impact of Tumor Biology and Social Determinants on Time to Diagnosis and Stage at Presentation of Wilms Tumor
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View abstract on PubMed
Summary
This summary is machine-generated.Time to diagnosis in Wilms tumor may depend on tumor aggressiveness, while delays are linked to patient barriers like socioeconomic status. Further research is needed to understand these complex diagnostic factors.
Area Of Science
- Pediatric Oncology
- Cancer Disparities Research
- Tumor Biology
Background
- Delays in diagnosis and time to diagnosis are often conflated in cancer disparity research.
- These terms may represent distinct concepts influenced by tumor biology versus patient-related factors.
- Understanding these differences is crucial for addressing disparities in pediatric cancer care.
Purpose Of The Study
- To differentiate between time to diagnosis and delays in diagnosis for Wilms tumor.
- To investigate the roles of intrinsic tumor factors (biology) and extrinsic patient barriers (socioeconomic status) in diagnostic timing.
- To determine the association of these factors with disease stage at diagnosis.
Main Methods
- Retrospective study of 306 Wilms tumor patients (1971-2016).
- Identified patient barriers (extrinsic) and tumor biology markers (intrinsic: unfavorable histology, loss of heterozygosity).
- Utilized multivariable logistic regression to analyze diagnostic timing and stage at diagnosis.
Main Results
- Patients with Medicaid experienced longer diagnostic times (>4 days) compared to privately insured patients.
- Housing concerns were associated with delayed diagnosis (>9 days).
- Aggressive tumor biology correlated with higher stage at diagnosis, but patient barriers did not.
Conclusions
- Diagnostic timing in Wilms tumor is complex, influenced by both tumor biology and patient-related barriers.
- Patient barriers did not directly correlate with higher stage at diagnosis in this study.
- Further investigation is required to fully elucidate the interplay between tumor biology, patient barriers, and diagnostic outcomes.
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