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Mussel inspired sequential protein delivery based on self-healing injectable nanocomposite hydrogel.
Xiao Shuai Han1, Peng Cheng Li1, Heng Tao Song2
1College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science and Technology, Xi'an 710021, PR China.
International Journal of Biological Macromolecules
|March 6, 2024
Summary
This study introduces a novel dynamic polysaccharide hydrogel for sequential protein drug delivery. The mussel-inspired nanocomposite hydrogel, containing polydopamine nanoparticles, enables controlled release of different proteins.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Polysaccharide hydrogels offer potential for protein drug delivery due to their self-healing and injectable properties.
- Designing dynamic hydrogels for sequential protein release remains a significant challenge.
- Reversible characteristics are crucial for advanced drug delivery applications.
Purpose of the Study:
- To develop a novel mussel-inspired dynamic polysaccharide hydrogel for sequential protein drug delivery.
- To investigate the role of polydopamine nanoparticles (PDA NPs) in hydrogel properties and drug release.
- To achieve sustained and sequential release of different proteins, such as vascular endothelial growth factor (VEGF) and bovine serum albumin (BSA).
Main Methods:
- Fabrication of a nanocomposite hydrogel (PDA NPs@OHA-l-CEC) using oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CEC) crosslinked via imine bonds.
- Doping of polydopamine nanoparticles (PDA NPs) into the polysaccharide hydrogel matrix.
- Adjustment of OHA oxidation degree to control crosslinking density and protein release rates.
- Analysis of protein release kinetics using established models.
Main Results:
- The developed PDA NPs@OHA-l-CEC hydrogel exhibited injection, self-healing, and biodegradability.
- The hydrogel successfully achieved sustained and sequential release of VEGF and BSA.
- PDA NPs acted as secondary release structures and formed non-covalent interactions, influencing release profiles.
- VEGF release followed Fickian diffusion, while BSA release followed Super Case II transport.
Conclusions:
- The novel mussel-inspired hydrogel system enables controlled sequential release of protein drugs.
- This biocompatible system holds promise for multi-stage synergistic drug delivery applications.
- Dynamic hydrogel properties can be tuned by adjusting crosslinking density for tailored drug release profiles.
