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  11. Analyses Of Quality Of Life In Cancer Drug Trials - A Review Of Measurements And Analytical Choices In Post-reimbursement Studies

Analyses of quality of life in cancer drug trials - a review of measurements and analytical choices in post-reimbursement studies

Mikael Svensson1,2, Gabriella Chauca Strand3, Carl Bonander3,4

  • 1Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, 1225 Center Dr, Gainesville, FL, 32610, USA. svensson.kmikael@ufl.edu.

BMC Cancer
|March 6, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Quality of life (QoL) data for cancer drugs in Sweden needs better measurement and analysis. Stricter adherence to best practices is crucial for reliable patient and decision-maker input.

Area of Science:

  • Oncology
  • Health Economics
  • Clinical Trial Methodology

Background:

  • Confirmatory evidence of overall survival (OS) and quality of life (QoL) is vital for drugs with limited initial benefit data.
  • Appropriate measurement and analysis are essential for QoL data to inform patients and decision-makers.
  • Cancer drugs reimbursed in Sweden between 2010-2020 with limited evidence were assessed.

Conclusions:

  • Significant improvements are needed in the measurement and analysis of QoL data for cancer drugs in the reviewed sample.
  • Enhanced adherence to best-practice guidelines is necessary for QoL assessments to provide meaningful input.
  • The study highlights the need for more rigorous QoL data handling in clinical trials supporting drug reimbursement.
Keywords:
CancerHealth-related quality of lifePatient-reported outcomesQuality assessment

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