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Complete transverse basilar cleft associated with hemifacial microsomia.
Laphatrada Yurasakpong1,2, Athikhun Suwannakhan1,2, Joe Iwanaga3,4,5,6
1Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand.
Anatomy & Cell Biology
|March 7, 2024
Summary
A rare transverse basilar cleft (TBC), a clivus variation, was identified in a patient with hemifacial microsomia (HFM). This finding suggests a potential link between clival development and HFM syndrome.
Area of Science:
- Anatomy
- Genetics
- Radiology
Background:
- The clivus, a crucial anatomical structure at the skull base, can exhibit rare variations.
- Hemifacial microsomia (HFM) is a congenital disorder affecting facial development.
Observation:
- A computed tomography scan revealed a unilateral transverse basilar cleft (TBC) in the clivus of an 18-year-old female.
- The patient also presented with right-sided HFM, including mandibular and maxillary hypoplasia and temporomandibular joint displacement.
Findings:
- The identified TBC is an extremely rare clival variation, specifically a fissure between the basioticum and basioccipital bones.
- This represents the first reported instance of TBC associated with HFM.
Implications:
- This case highlights a potential complex relationship and possible genetic or molecular association between clival development and HFM syndrome.
- Further research into clival variations and their connection to craniofacial developmental disorders is warranted.
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