Related Experiment Video
Updated: Jul 1, 2025
06:33
3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
11.5K
Congenital Toxoplasmosis and Long-term Outcomes
Ozlem Ozgur Gundeslioglu1, Zeliha Haytoglu2, Ebru Esen3
1Cukurova University Faculty of Medicine, Department of Pediatric Infectious Diseases, Adana, Türkiye.
Turkiye Parazitolojii Dergisi
|March 7, 2024
Summary
Congenital toxoplasmosis (CT) can cause severe vision, hearing, and neurodevelopmental issues. Early diagnosis and treatment of infants with CT are crucial to prevent long-term complications.
Area of Science:
- Medical Research
- Infectious Diseases
- Pediatrics
Background:
- Congenital toxoplasmosis (CT) poses significant risks for severe early and late-onset complications in children.
- Understanding the demographic, clinical, and treatment profiles of CT is vital for effective management.
Purpose of the Study:
- To evaluate the demographic, clinical, and treatment characteristics of patients diagnosed with congenital toxoplasmosis.
- To highlight the long-term complications associated with congenital toxoplasmosis.
Main Methods:
- Retrospective analysis of patients with CT followed between 2010 and 2022.
- Diagnosis involved Toxoplasma IgM, IgG, IgG avidity, and PCR tests, alongside clinical evaluation.
- Maternal and infant data, including treatment and outcomes, were collected.
Main Results:
- Eighteen children with CT were studied; ocular involvement (55.5%) was most common, followed by hydrocephalus and intracranial calcification (27.7%).
- Long-term sequelae included neurodevelopmental retardation (38.8%), hearing loss (11.1%), seizures (16.6%), and microcephaly (11.1%).
- Maternal spiramycin treatment during pregnancy showed some protective effect, though microphthalmia occurred in one case.
Conclusions:
- Congenital toxoplasmosis leads to severe sequelae affecting vision, hearing, and neurodevelopment.
- Early detection of Toxoplasma infection during pregnancy and prompt infant treatment are critical for preventing severe outcomes.
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