Innate lymphoid cells in neuroinflammation.
Daria Kveštak1, Andrea Mihalić1, Stipan Jonjić1,2
1Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Frontiers in Cellular Neuroscience
|March 7, 2024
Summary
Innate lymphoid cells (ILCs) are key immune cells in the central nervous system (CNS). This review details their roles in maintaining CNS health and responding to conditions like neuroinflammation and infection.
Area of Science:
- Neuroimmunology
- Cellular Biology
- Tissue Homeostasis
Background:
- Innate lymphoid cells (ILCs) are crucial for tissue homeostasis and early inflammatory responses.
- ILCs are typically found in the choroid plexus and meninges, with minimal presence in the CNS parenchyma under normal conditions.
Purpose of the Study:
- To provide a comprehensive overview of innate lymphoid cell involvement and function within the CNS.
- To explore the roles of ILCs in physiological states and pathological conditions including CNS infections, autoimmune diseases, neurodegeneration, and injury.
Main Methods:
- Literature review and synthesis of existing research on ILCs in the CNS.
Main Results:
- ILCs are present in the CNS, primarily in the meninges and choroid plexus during homeostasis.
- Pathological conditions like autoimmune neuroinflammation and viral CNS infections trigger ILC infiltration into the CNS parenchyma.
Conclusions:
- ILCs play significant roles in the CNS, both in maintaining normal tissue function and in responding to disease.
- Understanding ILC dynamics in the CNS is critical for developing therapeutic strategies for neurological disorders.
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