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Related Experiment Video

Updated: Jul 1, 2025

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Myxoid pleomorphic liposarcoma.

Sharareh Fadaei¹, Fleur Cordier^1,2, Liesbeth Ferdinande¹

¹Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.

Histology and Histopathology

|March 7, 2024

Summary

Myxoid pleomorphic liposarcoma (MPL) is a rare, aggressive tumor distinct from other liposarcomas. This review summarizes MPLs, aiding future diagnosis and treatment strategies for this challenging cancer.

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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

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Published on: June 13, 2018

Area of Science:

Oncology
Pathology
Genetics

Background:

Myxoid pleomorphic liposarcoma (MPL) is a rare adipocytic tumor recently classified by the WHO.
MPLs present unique histological features, combining myxoid and pleomorphic liposarcoma characteristics.
These tumors predominantly affect young women, often found in the mediastinum.

Purpose of the Study:

To provide a comprehensive review of Myxoid Pleomorphic Liposarcoma (MPL).
To consolidate existing knowledge on MPLs from case reports and studies.
To offer insights for improved diagnosis, treatment, and patient outcomes.

Main Methods:

Literature review of documented case reports and studies on MPLs.
Analysis of histological, molecular, and clinical data from existing literature.
Synthesis of information to characterize MPLs.

Main Results:

MPLs are genetically distinct, lacking FUS/EWSR1::DDIT3 fusions and MDM2/CDK4 amplifications.
MPLs exhibit complex karyotypes, aggressive behavior, high recurrence, and metastatic potential.
Prognosis is poor, with a median survival of approximately 22.6 months.

Conclusions:

MPLs represent a unique entity within liposarcomas with distinct molecular and clinical features.
Understanding MPLs' characteristics is crucial for developing targeted diagnostic and therapeutic approaches.
Further research is needed to improve outcomes for patients with this rare tumor.