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Updated: Jul 1, 2025

Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
Published on: September 16, 2013
Microbial Primer: Lipopolysaccharide - a remarkable component of the Gram-negative bacterial surface
Leah M VanOtterloo1, M Stephen Trent1,2
1Department of Microbiology, College of Arts and Sciences, University of Georgia, Athens, Georgia, USA.
Abstract:
Lipopolysaccharide (LPS) is a fundamental tripartite glycolipid found on the surface of nearly all Gram-negative bacteria. It acts as a protective shield for the bacterial cell and is a potent agonist of the innate immune system. This primer serves to introduce the basic properties of LPS, its function in bacterial physiology and pathogenicity, and its use as a therapeutic target.
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