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Updated: Jul 1, 2025

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

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The bidirectional links between coronavirus disease 2019 and Alzheimer's disease

Ali Nouraeinejad1

  • 1Faculty of Brain Sciences, Institute of Ophthalmology, University College London (UCL), London, UK.

The International Journal of Neuroscience
|March 7, 2024
PubMed

Insights

This review examines the connection between Coronavirus disease 2019 (COVID-19) and Alzheimer's disease. Understanding shared risk factors may help create better treatments for both conditions.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Gerontology

Background:

  • Coronavirus disease 2019 (COVID-19) poses significant risks, especially to the elderly and those with pre-existing conditions.
  • Patients with Alzheimer's disease exhibit heightened vulnerability to severe COVID-19 outcomes.
  • Emerging evidence suggests shared risk factors between COVID-19 and Alzheimer's disease.

Purpose of the Study:

  • To explore the intricate bidirectional relationship between COVID-19 and Alzheimer's disease.
  • To identify common pathological pathways and risk factors linking both diseases.
  • To inform the development of integrated therapeutic strategies.

Main Methods:

  • Systematic literature review of recent studies on COVID-19 and Alzheimer's disease.
  • Analysis of epidemiological data and clinical observations.
  • Examination of molecular and cellular mechanisms potentially involved.

Main Results:

  • COVID-19 infection may exacerbate Alzheimer's pathology, potentially accelerating cognitive decline.
  • Shared risk factors, including age, cardiovascular issues, and inflammatory responses, are identified.
  • The review highlights potential viral impacts on neuroinflammation and amyloid-beta aggregation.

Conclusions:

  • A complex interplay exists between COVID-19 and Alzheimer's disease, necessitating further investigation.
  • Understanding these links is crucial for managing patients with both conditions.
  • This knowledge can guide the development of novel interventions targeting shared pathways.

Keywords:
Alzheimer’s diseaseCOVID-19central nervous systemneuroinflammationneuropsychiatric symptoms

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