Related Experiment Video
Updated: Jul 1, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
38.9K
A Prospective, Monocentric Case-Control Study on Uncontrolled Psoriasis as Independent Risk Factor for a
Tom M Hillary1, Tine Vanhoutvin2, Miet Peeters3
1Dermatology Department, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium. Tom.Hillary@uzleuven.be.
Dermatology and Therapy
|March 7, 2024
Summary
Psoriasis patients exhibit a hypercoagulable clot lysis profile (CLP) with increased clotting and reduced lysis compared to healthy individuals. Anti-inflammatory treatment significantly improved this clot lysis profile in psoriasis patients.
Area of Science:
- Dermatology
- Hematology
- Thrombosis Research
Background:
- Psoriasis is a chronic inflammatory disease linked to an increased risk of venous thromboembolism (VTE).
- The clot lysis profile (CLP) assesses both clotting tendency and fibrinolysis, offering insights into coagulation dynamics.
- Previous research suggests potential alterations in CLP in chronic inflammatory conditions.
Purpose of the Study:
- To compare the clot lysis profile (CLP) in patients with uncontrolled psoriasis against age- and sex-matched healthy controls (HC).
- To investigate whether successful anti-inflammatory treatment can normalize the CLP in psoriasis patients.
- To establish the relationship between psoriasis severity and CLP parameters.
Main Methods:
- A prospective study involving 87 patients with uncontrolled psoriasis (Psoriasis Area and Severity Index [PASI] or Body Surface Area [BSA] > 10) and 87 HC.
- CLP parameters, including amplitude, area under the curve (AUC), and 50% clot lysis time, were measured.
- Patient samples were collected before treatment and after achieving disease control (PASI < 3).
Main Results:
- Psoriasis patients displayed significantly higher median amplitude and AUC at baseline compared to HC (p < 0.0001).
- These differences in amplitude remained significant after adjusting for confounders like BMI, smoking, psoriatic arthritis, hypertension, and diabetes.
- Anti-inflammatory treatment led to a significant reduction in amplitude (p = 0.0365).
Conclusions:
- This study is the first to prospectively compare the CLP in psoriasis patients with HC.
- Psoriasis patients exhibit a hypercoagulable CLP, characterized by increased amplitude and AUC, indicating enhanced clotting and/or reduced lysis.
- Successful anti-inflammatory treatment effectively reduced the amplitude, suggesting a normalization of the hypercoagulable state.
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