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  11. B-cell-mediated Immunity Predicts Survival Of Patients With Estrogen Receptor-positive Breast Cancer.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. B-cell-mediated Immunity Predicts Survival Of Patients With Estrogen Receptor-positive Breast Cancer.

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B-Cell-Mediated Immunity Predicts Survival of Patients With Estrogen Receptor-Positive Breast Cancer.

Seungbok Lee1, Byung-Hee Kang2,3, Han-Byoel Lee4,5,6

  • 1Department of Genomic Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

JCO Precision Oncology
|March 7, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Researchers identified distinct molecular subtypes in estrogen receptor-positive breast cancer (ER+ BC). High B-cell immune activity in ER+ BC subtypes correlates with better prognosis, potentially guiding precision treatments.

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Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Estrogen receptor-positive (ER+) breast cancer (BC) is the most common type but shows significant clinical heterogeneity.
  • Precision treatment strategies require a deeper understanding of ER+ BC molecular subtypes and their tumor microenvironment.

Purpose of the Study:

  • To identify novel molecular subtypes of ER+ BC based on gene expression profiles.
  • To investigate the association of these subtypes with tumor microenvironment, specifically immune cell composition.
  • To evaluate the prognostic implications of identified ER+ BC subtypes.

Main Methods:

  • RNA-sequencing data from 113 BC patients were analyzed, focusing on 44 ER+ BC cases for subclassification.
  • PAM50 intrinsic subtypes were used for initial classification.
  • The Cancer Genome Atlas (TCGA) dataset served as a validation cohort.
  • Immune cell composition was estimated using CIBERSORT.

    • Main Results:

    • Principal component analysis revealed two distinct subgroups within ER+ BC, independent of luminal A/B classification.
    • These subgroups were characterized by differential expression of immunoglobulin and B-cell-related genes.
    • A validation cohort confirmed two subgroups based on B-cell-specific gene expression, with higher B-cell activity linked to better prognosis.

    Conclusions:

    • A transcriptomic approach highlights the significance of B-cell immunity in ER+ BC.
    • This molecular phenotype may serve as a prognostic marker for ER+ BC.
    • Further research could establish B-cell immunity as a predictor for chemotherapy or immunotherapy response in ER+ BC patients.