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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
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Association of Timely Comprehensive Genomic Profiling With Precision Oncology Treatment Use and Patient Outcomes in
Jeff Yorio1, Katherine T Lofgren2, Jessica K Lee2
1Texas Oncology, Austin, TX.
JCO Precision Oncology
|March 7, 2024
Summary
Timely comprehensive genomic profiling (CGP) in advanced non-small-cell lung cancer improves targeted therapy use and reduces ineffective treatments. This enhances patient care by optimizing first-line treatment decisions and potentially delaying therapy discontinuation.
Area of Science:
- Oncology
- Genomics
- Biomarker Testing
Background:
- Timely biomarker testing is crucial for advanced non-small-cell lung cancer (aNSCLC) but remains a challenge.
- Informing first-line (1L) treatment decisions requires timely receipt of comprehensive genomic profiling (CGP).
Purpose of the Study:
- To evaluate the quality-of-care implications of timely CGP for aNSCLC patients.
- To assess how closing the gap in timely CGP impacts 1L treatment selection and patient outcomes.
Main Methods:
- Utilized a real-world clinicogenomic database of aNSCLC patients.
- Analyzed testing and 1L treatment patterns post-pembrolizumab combination approval.
- Dichotomized patients based on CGP result availability before or after 1L therapy initiation.
Main Results:
- Timely CGP increased matched targeted therapy use (17% vs 2.8%) and precision immune checkpoint inhibitor (ICPI) use (18% vs 3.9%).
- Timely CGP decreased ICPI use in ALK/EGFR/RET/ROS1-positive patients, reducing ineffective therapy costs by $13,659.37 per patient.
- Timely CGP improved time to therapy discontinuation (median 10 vs 3.9 months) in 1L driver-positive patients.
Conclusions:
- Timely CGP is associated with improved quality of patient care in aNSCLC.
- It enhances the use of matched targeted therapies and reduces reliance on ineffective ICPIs.
- Timely CGP positively impacts treatment duration and potentially avoids costly, ineffective therapies.
