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Updated: Jul 1, 2025
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
Published on: May 3, 2024
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Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis
Asif Ahmad Bhat1, Yassine Riadi2, Muhammad Afzal3
1School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, India.
Pathology, Research and Practice
|March 7, 2024
Summary
Non-coding RNAs (ncRNAs) significantly regulate pyroptosis in sepsis. Understanding these interactions offers new diagnostic and therapeutic strategies for this life-threatening condition.
Area of Science:
- Molecular Biology
- Immunology
- Genetics
Background:
- Sepsis is a life-threatening condition caused by dysregulated host response to infection.
- Non-coding RNAs (ncRNAs) play crucial roles in cellular regulation.
- Pyroptosis, a programmed cell death pathway, is implicated in sepsis pathophysiology.
Purpose of the Study:
- To review the role of ncRNAs in regulating pyroptosis during sepsis.
- To explore the diagnostic and therapeutic potential of targeting ncRNAs in sepsis.
- To elucidate the complex interactions between ncRNAs and pyroptosis.
Main Methods:
- Comprehensive literature analysis of ncRNA-mediated regulation in sepsis.
- Examination of diverse ncRNA classes: miRNAs, lncRNAs, and circRNAs.
- Investigation of ncRNAs' roles as facilitators and inhibitors in pyroptosis.
Main Results:
- ncRNAs profoundly influence molecular pathways controlling pyroptosis in sepsis.
- Specific ncRNAs (miRNAs, lncRNAs, circRNAs) act as modulators of pyroptotic processes.
- Targeting ncRNAs presents potential for novel sepsis diagnostics and therapeutics.
Conclusions:
- The intricate crosstalk between ncRNAs and pyroptosis is central to sepsis pathogenesis.
- Targeting ncRNAs offers promising avenues for developing effective sepsis interventions.
- Further understanding of ncRNA-pyroptosis axis can advance sepsis management strategies.
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