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Spatial mapping of corneal biomechanical properties using wave-based optical coherence elastography.

Qingying Wang1, Yulei Chen2, Kexin Shen1

  • 1Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Journal of Biophotonics
|March 7, 2024
PubMed
Summary

This study introduces a non-contact optical coherence elastography system to map corneal elasticity. The system effectively quantifies biomechanical changes, aiding in keratoconus and corneal crosslinking assessment.

Keywords:
corneacrosslinkingoptical coherence elastographytwo‐dimensional

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Area of Science:

  • Biomedical Optics
  • Ophthalmology
  • Biomechanical Engineering

Background:

  • Keratoconus progression and corneal crosslinking efficacy require accurate mechanical property quantification.
  • Current methods for assessing corneal biomechanics can be invasive or lack resolution.

Purpose of the Study:

  • To develop and validate a non-contact, non-invasive wave-based optical coherence elastography system for corneal elasticity mapping.
  • To assess the system's capability in measuring elastic properties and spatial resolution using phantoms and porcine corneas.

Main Methods:

  • Utilized air-pulse stimulation to induce elastic waves in the cornea.
  • Employed optical coherence elastography to capture wave propagation and calculate elasticity.
  • Validated the system with homogeneous and dual concentration phantoms, achieving 0.91 mm spatial resolution.
  • Mapped elastic wave velocity distribution in porcine corneas before and after corneal crosslinking.

Main Results:

  • The system successfully created a two-dimensional map of corneal elasticity.
  • Phantom measurements verified elastic mapping capabilities and spatial resolution.
  • Significant biomechanical changes were observed in the crosslinked region of porcine corneas.
  • Demonstrated the system's ability to detect alterations in corneal mechanical properties post-treatment.

Conclusions:

  • The developed wave-based optical coherence elastography system is non-invasive and offers high resolution for corneal elasticity mapping.
  • This technology shows significant potential for clinical applications in diagnosing keratoconus and evaluating corneal crosslinking outcomes.