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Overview of reemerging mpox infection with a focus on neurological manifestations
Mohammed Alissa1, Abdullah Alghamdi1, Suad A Alghamdi1
1Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Abstract:
Mpox, a reemerging zoonotic disease caused by the mpox virus, has garnered increasing attention due to its potential for severe clinical manifestations. While the cutaneous and systemic presentations of mpox have been well-documented, its neurological complications have recently emerged as an area of concern. This review provides a brief overview of the neurological aspects of mpox infection, highlighting the key findings and challenges in understanding and managing these complications. Neurological manifestations in mpox patients range from mild symptoms such as headaches and dizziness to more severe conditions, including encephalitis and seizures. The pathogenesis of neurological involvement is not yet fully elucidated but is thought to involve viral dissemination to the central nervous system. This dissemination may occur through haematogenous or neuronal routes, contributing to the diverse clinical spectrum observed. Early recognition and diagnosis of neurological complications in mpox are crucial for implementing appropriate therapeutic interventions and improving patient outcomes.
Insights
Mpox virus infections can cause neurological issues, ranging from headaches to severe encephalitis. Early diagnosis of these mpox complications is vital for effective treatment and better patient outcomes.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Mpox is a reemerging zoonotic disease caused by the mpox virus.
- While cutaneous and systemic mpox manifestations are known, neurological complications are a growing concern.
Purpose of the Study:
- To provide an overview of the neurological aspects of mpox infection.
- To highlight key findings and challenges in understanding and managing mpox-related neurological complications.
Main Methods:
- This is a review article, synthesizing existing literature on mpox and neurological complications.
- Key findings from reported cases and studies were analyzed.
Main Results:
- Neurological manifestations in mpox patients vary widely, including headaches, dizziness, encephalitis, and seizures.
- The exact pathogenesis of neurological involvement is unclear, but viral spread to the central nervous system is suspected via hematogenous or neuronal pathways.
Conclusions:
- Neurological complications represent a significant concern in mpox infections.
- Early recognition and diagnosis are critical for timely therapeutic interventions and improved patient outcomes in mpox cases.
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