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[Expression of FAT1 in Lung Adenocarcinoma and Its Relationship 
with Immune Cell Infiltration]

  • 0Department of Thoracic Surgery, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832003, China.
Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer +

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March 7, 2024

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March 7, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

High FAT atypical cadherin 1 (FAT1) mRNA expression in lung adenocarcinoma correlates with poor patient prognosis. FAT1 may serve as a potential biomarker for lung cancer detection and treatment.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genomics

Context

  • Lung adenocarcinoma is a major cause of cancer mortality.
  • FAT atypical cadherin 1 (FAT1) mutations are frequent in lung adenocarcinoma.
  • FAT1 is implicated in cell adhesion, proliferation, and differentiation.

Purpose

  • Investigate FAT1 expression in lung adenocarcinoma.
  • Determine the relationship between FAT1 expression and patient prognosis.
  • Explore FAT1's association with immune infiltration.

Summary

  • FAT1 mRNA expression is significantly elevated in lung adenocarcinoma tissues compared to adjacent tissues.
  • Higher FAT1 expression is linked to reduced survival rates in lung adenocarcinoma patients.
  • FAT1 expression is associated with tumor development pathways and immune cell infiltration.

Impact

  • FAT1 serves as a potential prognostic biomarker for lung adenocarcinoma.
  • Understanding FAT1's role may inform novel therapeutic strategies.
  • Findings contribute to the molecular understanding of lung adenocarcinoma progression.

Keywords: