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Related Experiment Video

Updated: Jul 1, 2025

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

Rift Valley Fever.

J Brian Kimble¹, Leela Noronha¹, Jessie D Trujillo²

¹Foreign Arthropod-Borne Animal Diseases Research Unit, National Bio and Agro-Defense Facility, USDA, ARS, Manhattan, KS, USA.

The Veterinary Clinics of North America. Food Animal Practice

|March 7, 2024

Summary

This summary is machine-generated.

Rift Valley fever (RVF) is a zoonotic disease affecting livestock and humans, primarily spread by infected mosquitoes. This viral illness, caused by Rift Valley fever virus (RVFV), is endemic in Africa and the Arabian Peninsula.

Keywords:

Abortion Cattle Goats Hemorrhagic fever Rift valley fever Sheep

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Area of Science:

Veterinary Medicine
Infectious Diseases
Public Health

Background:

Rift Valley fever (RVF) is a significant zoonotic viral disease impacting livestock like cattle, sheep, and goats.
The disease is caused by the Rift Valley fever virus (RVFV), which can also infect humans.
RVFV is transmitted primarily through arthropod vectors, mainly infected mosquitoes.

Purpose of the Study:

To provide a comprehensive overview of Rift Valley fever (RVF).
To detail the causative agent, Rift Valley fever virus (RVFV).
To outline the transmission dynamics and geographical distribution of RVFV.

Main Methods:

Literature review of RVF and RVFV.
Analysis of epidemiological data on RVF outbreaks.
Characterization of RVFV isolation and identification.

Main Results:

RVFV affects domestic and wild ruminants and can infect humans.
Primary transmission occurs via infected mosquito bites or exposure to infected blood.
RVFV was first isolated in Kenya in 1931 and is endemic in sub-Saharan Africa, the Arabian Peninsula, and Mayotte.

Conclusions:

RVF poses a substantial threat to animal health and public health in endemic regions.
Understanding RVFV transmission is crucial for effective disease control and prevention strategies.
Continued surveillance and research are necessary to manage the spread of RVFV.