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Updated: Jul 1, 2025
Quantitative Autonomic Testing
Published on: July 19, 2011
Risk Factors Associated with Unsuccessful High-Resolution Manometry
Vishesh V Patel1, David E Reed1,2, David M Rodrigues3,4
1Department of Medicine, Queen's University, Kingston, ON, Canada.
High-resolution manometry (HRM) testing failure occurred in 18% of cases. Nausea, vomiting, dyspepsia, and achalasia are key risk factors for unsuccessful esophageal manometry, impacting diagnosis.
Area of Science:
- Gastroenterology
- Esophageal Physiology
Background:
- High-resolution manometry (HRM) is crucial for assessing esophageal motor function.
- Inaccurate HRM testing can lead to diagnostic delays and affect treatment decisions.
Purpose of the Study:
- To quantify the incidence of failed HRM tests.
- To identify patient-specific risk factors associated with HRM test failure.
Main Methods:
- Retrospective analysis of 152 HRM tests conducted between September 2021 and August 2022.
- Failed tests were defined as those uninterpretable per Chicago guidelines.
- Comparison of successful versus unsuccessful HRM based on indications, demographics, and medical history.
Main Results:
- 18% (28/152) of HRM tests were unsuccessful.
- Nausea, vomiting, and dyspepsia were linked to probe intolerance (ORs 13.8-20.3).
- Achalasia history correlated with catheter curling (OR 13.2).
- Repeat HRM with endoscopic placement was successful in all seven patients.
Conclusions:
- Nausea/vomiting and dyspepsia increase the risk of probe intolerance during HRM.
- Achalasia is a risk factor for catheter curling, leading to test failure.
- Addressing these risk factors may improve HRM success rates and streamline patient care.
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