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Related Experiment Video

Updated: Jul 1, 2025

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Deconstructing neutrophil to lymphocyte ratio (NLR) in early breast cancer: lack of prognostic utility and biological

Esmeralda Garcia-Torralba1,2,3, Miguel Pérez Ramos4, Alejandra Ivars Rubio1,2,3

  • 1Department of Medical Oncology, Hospital Universitario Morales Meseguer, Murcia, 30008, Spain.

Breast Cancer Research and Treatment
|March 7, 2024
PubMed
Summary
This summary is machine-generated.

The neutrophil to lymphocyte ratio (NLR) shows limited utility as a prognostic biomarker in early breast cancer. This study found no significant correlation between NLR and survival outcomes or tumor immune microenvironment in breast cancer patients.

Keywords:
Early breast cancerNeutrophil-to-lymphocyte ratioPrognosisTumor infiltrating lymphocytes

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Area of Science:

  • Oncology
  • Immunology
  • Biomarker Research

Background:

  • The neutrophil to lymphocyte ratio (NLR) is a proposed biomarker for immune response and inflammation.
  • Its prognostic value and biological associations in breast cancer (BC) remain unclear.

Purpose of the Study:

  • To evaluate the prognostic utility of NLR in early breast cancer.
  • To investigate the biological correlates of NLR, including its relationship with tumor-infiltrating lymphocytes.

Main Methods:

  • Analysis of a cohort of 959 women with early breast cancer.
  • Evaluation of clinical data, survival outcomes, NLR, and stromal tumor-infiltrating lymphocytes (sTIL).

Main Results:

  • NLR showed weak association with Ki67 but no correlation with grade, histology, subtype, or stage.
  • No significant correlation was observed between NLR and sTIL.
  • Pre-treatment NLR did not predict relapse-free interval, breast cancer-specific survival, or overall survival in univariate or multivariate analyses.

Conclusions:

  • NLR appears to have limited utility as a prognostic biomarker in early breast cancer.
  • NLR does not correlate with the immune response within the tumor microenvironment in breast cancer.