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Brain tumour microstructure is associated with post-surgical cognition.
Maite Aznarez-Sanado1, Rafael Romero-Garcia2,3, Chao Li4,5,6
1School of Education and Psychology, University of Navarra, 31009, Pamplona, Spain.
Scientific Reports
|March 7, 2024
Summary
Brain tumor microstructure, measured by diffusion MRI, predicts cognitive decline after surgery. Specific tumor subregions impacting verbal skills also show greater functional interaction with the brain.
Area of Science:
- Neuroimaging
- Neurosurgery
- Cognitive Neuroscience
Background:
- Brain tumor microstructure may predict post-treatment cognitive function.
- Understanding this relationship is crucial for patient recovery and surgical planning.
Purpose of the Study:
- To investigate if intra-tumoral microstructure predicts cognitive recovery after surgery.
- To assess the role of tumor microstructure in functional brain interactions.
Main Methods:
- Diffusion-weighted MRI was used to quantify brain tumor microstructure.
- Two segmentation approaches (2D partition and Gaussian mixture modeling) were employed.
- BOLD signal analysis examined tumor-brain functional interactions.
Main Results:
- Tumor subregion volumes significantly predicted post-surgical verbal skill decline.
- These subregions exhibited greater functional interaction with unaffected brain regions.
- Multishell diffusion MRI-based microstructure correlated with cognitive recovery.
Conclusions:
- Intra-tumoral microstructure is a significant predictor of cognitive outcomes post-brain tumor surgery.
- Tumor subregions impacting cognition also show altered functional connectivity.
- Diffusion MRI provides valuable insights into brain tumor effects on cognitive function.
