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Published on: July 29, 2021
Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions
Ioana Medrea1, Stewart J Tepper2, Donliang Wang3
1SUNY Upstate Medical University, Syracuse, New York, USA. medreai@upstate.edu.
Background:
New guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies.
Main Body:
We present non-inferiority trials to overcome ethical issues with placebo use, and additionally discuss issues with trial recruitment.
Conclusions:
We highlight some possible issues and solutions to be considered with the recently published cluster headache trial guidelines.
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