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  1. Home
  3. Is There A Consensus On The Location And Composition Of The Human Subplate?
  1. Home
  3. Is There A Consensus On The Location And Composition Of The Human Subplate?

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Is there a consensus on the location and composition of the human subplate?

Gavin J Clowry1

  • 1Biosciences Institute and Centre for Transformative Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

The Journal of Comparative Neurology
|March 8, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

The human fetal cerebral cortex subplate is significantly wider than the cortical plate during the early second trimester. This finding highlights the subplate

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Human Embryology

Background:

  • The developing human brain exhibits distinct structural layers.
  • Understanding the relative proportions of these layers is crucial for comprehending neurodevelopmental trajectories.

Purpose of the Study:

  • To investigate the spatial relationship between the cortical plate and subplate in the early second-trimester human fetal cerebral cortex.
  • To characterize the extent of the subplate during this critical developmental window.

Main Methods:

  • Immunohistochemical staining of human fetal cerebral cortex tissue.
  • Utilized a synaptic marker (visualized in red) to delineate neuronal structures.
  • Microscopic examination of the cortical wall architecture.

Main Results:

  • The subplate region was observed to be substantially wider than the cortical plate.
  • Synaptic marker distribution indicated extensive neuronal organization within the subplate.
  • This disproportionate width is a key feature of early second-trimester corticogenesis.

Conclusions:

  • The subplate plays a major structural role in the early second-trimester human fetal cerebral cortex.
  • The findings provide critical insights into the developmental scaling of cortical layers.
  • This highlights the importance of the subplate in early brain development.