Texture analysis of 18F-FDG PET/CT and CECT: Prediction of refractoriness of Hodgkin lymphoma with mediastinal bulk involvement
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
![Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)](https://visualize.jove.com/wp-content/cache/webp/b8c229072d4d1c7083684b4991385327.webp)
View abstract on PubMed
Summary
This summary is machine-generated.Identifying patients with refractory Hodgkin Lymphoma (HL) is crucial. This study found that combining PET scan texture analysis (HISTO_EntropyPET) with clinical staging (GHSG stage) accurately predicts treatment refractoriness in newly diagnosed classical HL.
Area Of Science
- Oncology
- Radiology
- Medical Imaging
Background
- Accurate prognostication is vital for newly diagnosed classical Hodgkin Lymphoma (cHL) patients, especially those with mediastinal bulk, to identify high-risk individuals needing intensified therapy.
- Current prognostic models require enhancement with novel parameters to improve the stratification of patients likely to experience refractory disease.
Purpose Of The Study
- To investigate the predictive value of metabolic and texture features from baseline 18F-FDG PET/CT and CECT scans, alongside clinical data, for first-line therapy refractoriness in cHL.
- To identify independent predictors of refractoriness and assess their combined prognostic power.
Main Methods
- Retrospective review of 69 cHL patients who underwent staging PET and CECT scans.
- Extraction of metabolic and texture features using LIFEx software; analysis of clinical data, including GHSG staging.
- Statistical evaluation using ROC, Cox regression, and Kaplan-Meier analyses to determine prognostic significance and independent predictors.
Main Results
- GHSG stage was a significant clinical predictor of refractoriness.
- Second-order texture features from CECT (GLCM, GLRLM) and various PET features (SUVmean, shape, GLCM, GLRLM, NGLDM) showed prognostic power.
- HISTO_EntropyPET from PET scans and GHSG stage emerged as significant independent predictors at multivariate analysis.
Conclusions
- Radiomic features from PET/CT, particularly HISTO_EntropyPET, offer valuable prognostic information for mediastinal bulky cHL.
- Combining HISTO_EntropyPET with GHSG stage significantly improves the prediction of treatment refractoriness, identifying distinct risk groups.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radioactive Tracer: PET involves using biologically active molecules labeled with radioactive isotopes, known as tracers or radiotracers. The...