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A blended preconception lifestyle programme for couples undergoing IVF: lessons learned from a multicentre randomized
Tessy Boedt1, Eline Dancet2, Diane De Neubourg3
1Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Human Reproduction Open
|March 8, 2024
Summary
A blended preconception lifestyle program did not significantly improve pregnancy rates or lifestyle factors for couples undergoing IVF. The study was stopped early due to COVID-19, limiting its power and suggesting further research is needed.
Area of Science:
- Reproductive Medicine
- Lifestyle Interventions
- In Vitro Fertilization (IVF)
Background:
- Growing evidence links healthy lifestyles to IVF success.
- Mobile-based lifestyle programs for IVF couples lack RCT evaluation.
Purpose of the Study:
- To assess the impact of a blended preconception lifestyle program on reproductive and lifestyle outcomes in couples undergoing their first 12 months of IVF.
- To compare the blended program against an attention control group.
Main Methods:
- A multicenter randomized controlled trial (RCT) involving 211 couples undergoing IVF.
- Intervention group received a blended lifestyle program (mobile app, phone counseling) alongside standard care.
- Control group received standard care plus mobile phone treatment information.
Main Results:
- The intervention showed no meaningful effect on time to ongoing pregnancy (HR 0.94; 95% CI 0.63-1.4).
- No significant impact was observed on other reproductive or lifestyle outcomes.
- Program acceptability was moderate (6/10), but mobile app usage was low among men (38%) and women (9%).
Conclusions:
- The RCT was prematurely stopped due to the COVID-19 pandemic, limiting statistical power.
- Findings suggest the blended program did not significantly improve outcomes, potentially due to low app engagement.
- Further research is needed on optimal intervention design and engagement strategies for preconception lifestyle programs in IVF.
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