Related Experiment Video
Updated: Jul 1, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Characterizing Cannabis Use and Perceived Benefit in a Tertiary Headache Center Patient Sample
Brianna Starkey1, Godfrey D Pearlson1, Dale Bond1
1Hartford HealthCare Headache Center (BS, CG, AB, BMG, AV), Ayer Neuroscience Institute, West Hartford; Olin Neuropsychiatric Research Center (GDP), Institute of Living, Hartford; Department of Psychiatry and Neuroscience (GDP), Yale School of Medicine, New Haven; Department of Research (DB), Hartford Hospital/Hartford HealthCare; Department of Neurology (BMG, AV), University of Connecticut School of Medicine, Farmington; and Division of Health Psychology (AV), The Institute of Living/Hartford Hospital, CT.
Cannabis use in migraine patients shows significant perceived benefits for headache relief and associated symptoms. Many patients report reduced medication needs, though some lack guidance on product use.
Area of Science:
- Neurology
- Pharmacology
- Pain Management
Background:
- Cannabinoids show potential in migraine etiology and treatment.
- Limited research exists on cannabis use patterns in clinical headache populations.
Purpose of the Study:
- To investigate cannabis use patterns and perceived benefits in a clinical migraine patient sample.
- To understand how cannabis-based products affect migraine symptoms and associated risk factors.
Main Methods:
- Online survey administered to 1373 patients at a tertiary headache center.
- Data collected on cannabis use patterns, reasons for use, delivery methods, and perceived effects.
- Descriptive analyses performed on survey responses.
Main Results:
- 55.7% reported cannabis use in the past 3 years, with 65.8% using it for headache treatment.
- Majority reported improvements in headache intensity, duration, frequency, nausea, sleep, anxiety, and depression.
- 48.9% reported reduced need for other headache medications; 14.5% eliminated other medications.
Conclusions:
- This study is the largest to document cannabis use for migraine in a clinical sample.
- Most patients perceive significant benefits of cannabis for migraine management and associated symptoms.
- Further experimental trials are needed to validate these perceived benefits for migraine treatment and prevention.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Analgesia and Pain Management
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Hallucinogens and Psychedelics
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Altered States of Awareness
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...

