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Updated: Jul 27, 2026

A Model of Chronic Nutrient Infusion in the Rat
Published on: August 14, 2013
Effects of whole nutritional formula foods on nutritional improvement and intestinal flora in malnourished rats
Di Qu1, Pan-Pan Bo1,2, Zhi-Man Li1
1Institute of Special Animal and Plant Sciences Chinese Academy of Agricultural Sciences Changchun Jilin China.
Abstract:
Food for special medical purposes (FSMP) has received increasing attention as an enteral nutritional supplement. To investigate the effects of whole nutritional formula (WNF) containing dietary fiber and regular formula on nutritional supplementation and improvement of intestinal microecology, a rat malnutrition model was established with the formulations of WNF, FOS, and SDF (10, 20 g/kg bw) administered by gavage for 30 days. The results showed that the three formulations effectively improved the nutritional status of the malnourished rats, significantly increasing the level of IgG, increasing the abundance of Bacteroidetes, and affecting the content of propionic acid (PRO). The nutritional status of rats is closely related to growth performance, nutritional indexes, and immunoglobulin index, which cause changes in the composition of the intestinal flora. The above results showed that WNF positively affected the nutritional improvement, immune level, and intestinal health of rats. The comprehensive evaluation also suggested that the formulation containing ginseng water-soluble dietary fiber (ginseng-SDF) had the most significant effect.
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