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IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials
Choong-Hyun Koh1, Byung-Seok Kim2, Chang-Yuil Kang3
1Laboratory of Immune Regulation, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
Immune Network
|March 8, 2024
Summary
Interleukin-17 (IL-17) and Interleukin-21 (IL-21) are vital immune-modulating cytokines. Understanding their roles in immunity, inflammation, and disease is key to developing new therapies.
Area of Science:
- Immunology
- Molecular Biology
- Cellular Biology
Background:
- Interleukin-17 (IL-17) and Interleukin-21 (IL-21) are critical cytokines influencing immune responses.
- IL-17 is essential for defense against pathogens and maintaining microbiota balance, but its dysregulation causes inflammation and autoimmunity.
- IL-21 links innate and adaptive immunity, with imbalances contributing to autoimmune diseases and cancer.
Purpose of the Study:
- To provide an updated review of the immunobiology of IL-17 and IL-21.
- To explore the therapeutic potential of targeting IL-17 and IL-21 for various diseases.
- To enhance understanding of the complex roles these cytokines play in health and disease.
Main Methods:
- This review synthesizes current research and literature on IL-17 and IL-21.
- Analysis of published studies over the last two decades.
- Discussion of immunoregulatory functions and disease associations.
Main Results:
- IL-17 and IL-21 are central to diverse immune system functions.
- Dysregulation of these cytokines is linked to significant pathological conditions, including autoimmune disorders and cancer.
- Their dual role in host defense and disease pathogenesis is highlighted.
Conclusions:
- A comprehensive understanding of IL-17 and IL-21 immunobiology is crucial.
- Targeting IL-17 and IL-21 offers promising therapeutic avenues for immune-mediated diseases and cancer.
- Further research into these cytokines will advance immunological insights and treatment strategies.
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