Impact of resection for ovarian metastases from colorectal cancer and clinicopathologic analysis: A multicenter retrospective study in Japan

Hiroyasu Kagawa ^1,2, Yusuke Kinugasa ^1,3, Tomohiro Yamaguchi ^1,4

¹Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum.
²Division of Colon and Rectal Surgery Shizuoka Cancer Center Shizuoka Japan.
³Department of Gastrointestinal Surgery Tokyo Medical and Dental University Tokyo Japan.
⁴Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan.
⁵Department of Gastroenterological Surgery Osaka International Cancer Institute Osaka Japan.
⁶Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan.
⁷Department of Surgery Fujita Health University Hospital Toyoake Japan.
⁸Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery Nippon Medical School Tokyo Japan.
⁹Department of Surgical Oncology, Faculty of Medicine The University of Tokyo Tokyo Japan.
¹⁰Department of Gastroenterological Surgery Saitama Medical University International Medical Center Saitama Japan.
¹¹Department of Gastroenterological Surgery Aichi Cancer Center Hospital Nagoya Japan.
¹²Department of Gastroenterological Surgery Niigata Cancer Center Hospital Niigata Japan.
¹³Department of Gastroenterological Surgery Yamagata Prefectural Central Hospital Yamagata Japan.
¹⁴Department of Colorectal Surgery National Cancer Center Hospital Tokyo Japan.
¹⁵Department of Surgery Kurume University School of Medicine Kurume Japan.
¹⁶Department of Surgery Tochigi Cancer Center Tochigi Japan.
¹⁷Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences Mie University Graduate School of Medicine Tsu Japan.
¹⁸Department of Surgery Matsuyama Red Cross Hospital Matsuyama Japan.
¹⁹Division of Medical Safety Section Shiga University of Medical Science Otsu Japan.
²⁰Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine Nagoya Japan.
²¹Department of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
²²Department of Biostatistics, Clinical Research Center Shizuoka Cancer Center Shizuoka Japan.
²³Tokyo Medical and Dental University Tokyo Japan.
²⁴Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences Niigata University Niigata Japan.

⁰Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum.

Annals of Gastroenterological Surgery +

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March 8, 2024

View abstract on PubMed

Summary

Resecting ovarian metastases from colorectal cancer, even noncuratively, improves patient survival. Key prognostic factors include metastasis size, bilaterality, and presence of other organ involvement.

Area Of Science

Oncology
Surgical Oncology
Gastrointestinal Oncology

Background

Ovarian metastases from colorectal cancer are a significant clinical challenge.
Understanding the prognostic implications of surgical intervention is crucial for patient management.

Purpose Of The Study

To determine the significance of resecting ovarian metastases from colorectal cancer.
To identify clinicopathologic factors influencing prognosis in these patients.

Main Methods

A multicenter retrospective study involving 296 patients across 20 Japanese centers (2000-2014).
Evaluation of the impact of ovarian metastasis resection on patient prognosis.
Analysis of prognostic factors through multivariate analysis.

Main Results

Solitary ovarian metastases had a 3-year overall survival rate of 68.6%.
Curative resection (65.9%), noncurative resection (31.8%), and nonresection (6.1%) showed significant survival differences (P < 0.01).
Significant prognostic factors included metastasis size, bilaterality, peritoneal, pulmonary, liver, and remnant ovarian metastasis.

Conclusions

Curative resection for solitary ovarian metastases offers a relatively favorable prognosis, comparable to Stage IV colorectal cancer.
Both curative and noncurative resection of ovarian metastases provide a survival benefit.
Factors like large size, bilaterality, extraovarian spread, and residual disease impact prognosis.

Keywords:

colorectal cancer ovarian metastasis ovarian resection peritoneal metastasis prognostic factor