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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Survivin expression is associated with lymph node metastasis and short survival in patients with colorectal
Haneen Al-Maghrabi1, Zuhoor Al-Mansouri1, Jaudah Al-Maghrabi1,2
1Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre Jeddah, Saudi Arabi.
Background:
Survivin, a protein belonging to the Inhibitor of apoptosis (IAP) family, is the smallest member in terms of size. It works by preventing programmed cell death and regulating the advancement of the cell cycle. Being a part of the group of inhibitors associated with apoptosis, survivin is connected to increased aggression and negative prognosis in different malignancies, including colorectal cancer (CRC).
Materials And Methods:
Pathology tissue blocks of 209 primary tumors, and 44 adenomas, were used in this study, as well as an anti-Survivin antibody. A semiquantitative method was used to score the Survivin expression based on an evaluation of the percentage and intensity of nuclear expression.
Result:
Survivin expression was identified in 127 (60.8%) CRC samples and in 14 adenomas (31.8%). There was an association between positive Survivin immunostaining and lymph node metastasis (P: 0.001), lymphovascular invasion (P: 0.020), and short overall survival (Log-rank 4.012, P=0.045) and disease-free survival probabilities (Log Rank 4.921, P=0.027). There was no association between Survivin expression and age, gender, tumor location, size, stage, margin status, and tumor recurrence.
Conclusion:
Survivin immune expression is associated with worse prognoses in CRC patients. Survivin can be a potential disease biomarker and could be used in management plans for CRC patients.
Insights
Survivin protein expression is linked to poorer outcomes in colorectal cancer (CRC). This finding suggests survivin may serve as a valuable biomarker for CRC patient management and prognosis.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Survivin, an Inhibitor of Apoptosis (IAP) protein, regulates cell death and cell cycle progression.
- Elevated survivin levels correlate with increased tumor aggression and poor prognosis in various cancers, including colorectal cancer (CRC).
Purpose of the Study:
- To investigate the association between survivin expression and clinicopathological features in colorectal cancer.
- To evaluate survivin as a prognostic biomarker in CRC patients.
Main Methods:
- Analysis of survivin expression using immunohistochemistry in 209 primary CRC tumors and 44 adenomas.
- Semiquantitative scoring of nuclear survivin expression based on percentage and intensity.
Main Results:
- Survivin expression was detected in 60.8% of CRC samples and 31.8% of adenomas.
- Positive survivin immunostaining significantly correlated with lymph node metastasis (P=0.001), lymphovascular invasion (P=0.020), and reduced overall and disease-free survival (P=0.045 and P=0.027, respectively).
- No association was found between survivin expression and age, gender, tumor location, size, stage, margin status, or recurrence.
Conclusions:
- Survivin immune expression is a significant indicator of worse prognosis in colorectal cancer patients.
- Survivin holds potential as a valuable biomarker for disease management and treatment strategies in CRC.
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