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Updated: Jul 1, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis of pyrimido[4,5-b]quinolindiones and formylation: ultrasonically assisted reactions
Jorge Trilleras1, Andrés Charris-Molina2, Alfredo Pérez-Gamboa1
1Programa de Química, Facultad de Ciencias Básicas, Universidad del Atlántico, Puerto Colombia 81007, Colombia.
Abstract:
Ultrasound-assisted synthesis of pyrimidoquinolindione derivatives via a multicomponent reaction and subsequent formylation with Vilsmeier-Haack reagent were performed. Compounds were prepared by a one-pot method from aminopyrimidinones, dimedone and aromatic aldehydes through a Mannich-type reaction sequence, and then functionalized under ultrasound irradiation and Vilsmeier-Haack conditions to give β-chlorovinylaldehyde products. Ultrasonically assisted reactions, experimental simplicity, good yields without using metallic catalysts and the control of hazardous material release are features of this simple procedure.
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