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COVID-19 vaccines-associated Takotsubo cardiomyopathy: A narrative review

Shakiba Hassanzadeh1, Addi Suleiman2, Joaquim J Correia3

  • 1Department of Pathology, East Carolina University, Greenville, North Carolina, USA.

Le Infezioni in Medicina
|March 8, 2024
PubMed

Insights

Takotsubo cardiomyopathy (TTC) is a rare cardiac issue that has been reported following COVID-19 vaccination. While 16 cases are noted, a direct causal link requires further investigation, and vaccine benefits outweigh risks.

Area of Science:

  • Cardiology
  • Immunology
  • Public Health

Background:

  • Takotsubo cardiomyopathy (TTC) is a serious, temporary heart condition often affecting postmenopausal women after stress.
  • The COVID-19 pandemic led to widespread vaccination, with various cardiac events reported post-immunization.
  • A small number of TTC cases have been associated with COVID-19 vaccines.

Purpose of the Study:

  • To review the existing literature on Takotsubo cardiomyopathy.
  • To summarize reported cases of TTC following COVID-19 vaccination.
  • To discuss the potential association between COVID-19 vaccines and TTC incidence.

Main Methods:

  • Literature review of Takotsubo cardiomyopathy.
  • Analysis of reported cases of TTC post-COVID-19 vaccination.
  • Discussion of causality and risk-benefit analysis.

Main Results:

  • Sixteen cases of COVID-19 vaccination-associated TTC have been reported.
  • TTC is characterized by acute, reversible cardiac dysfunction.
  • No direct cause-and-effect relationship between COVID-19 vaccines and TTC is established.

Conclusions:

  • Further research is needed to explore the potential link between COVID-19 vaccines and TTC.
  • The benefits of COVID-19 vaccination significantly outweigh the potential risks of adverse events like TTC.
  • Continued monitoring of cardiac events post-vaccination is important.

Keywords:
COVID-19 vaccineCOVID-19 vaccine-associated Takotsubo cardiomyopathyTakotsubo cardiomyopathyTakotsubo syndromestress cardiomyopathy

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