Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design of novel PI3Kα and PI3Kγ inhibitors for cancer treatment using pharmacophore, protein-ligand contacts, and machine learning methods.

Journal of computer-aided molecular design·2026
Same author

Biofilm-Forming Ability of Infectious Organisms on Biomimetic SurfacesAn <i>In Vitro</i> and Machine-Learning Analysis.

ACS omega·2025
Same author

Ion release dynamics of bioactive resin cement under variable pH conditions.

Frontiers in oral health·2025
Same author

Rotational Alignment in Tibia Diaphyseal Fractures With the Suprapatellar Semiextended versus Standard Upper Entry Tibial Intramedullary Nailing: A Randomized Controlled Trial (RASPUTIN).

Journal of orthopaedic trauma·2025
Same author

Synthesis and characterization of TiO<sub>2</sub>-ZnO composite thin films for biomedical applications.

Biomedical materials (Bristol, England)·2025
Same author

Identification of Novel Potential Herbal Drug Targets against Beta-Catenin in the Treatment of Oral Squamous Cell Carcinoma.

Asian Pacific journal of cancer prevention : APJCP·2024

Related Experiment Video

Updated: May 10, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K

Injectable macroporous naturally-derived apatite bone cement as a potential trabecular bone substitute.

Vimal Kumar Dewangan1,2, T S Sampath Kumar1, Mukesh Doble2,3

  • 1Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai, India.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|March 8, 2024
PubMed
Summary

Novel bone cement from eggshell and fishbone shows improved properties for orthopedic applications. This natural apatite bone cement (FBDEAp) offers enhanced cell activity and resorbability, making it a promising trabecular bone substitute.

Keywords:
apatite bone cementeggshellfishboneinjectablemacroporoustrabecular bone substitute

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

12.7K
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

8.3K

Related Experiment Videos

Last Updated: May 10, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

12.7K
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

8.3K

Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Materials Chemistry

Background:

  • Bone defects pose significant clinical challenges, necessitating advanced bone graft substitutes.
  • Current synthetic bone cements have limitations in biocompatibility and integration.
  • Natural sources offer sustainable and potentially superior alternatives for bone regeneration.

Purpose of the Study:

  • To formulate a novel apatite bone cement using natural sources (eggshell and fishbone).
  • To evaluate the physicochemical, mechanical, and biological properties of the developed bone cement.
  • To assess its potential as a trabecular bone substitute in orthopedic applications.

Main Methods:

  • Hydroxyapatite from fishbone and tricalcium phosphate from eggshell were synthesized and mixed.
  • A liquid phase containing biopolymers (gelatin, chitosan) and polysorbate was used for cement preparation.
  • Characterization included X-ray diffraction, FTIR, SEM, micro-CT, compressive strength testing, and in vitro cell studies (MG63 cells).

Main Results:

  • The fishbone and eggshell-derived apatite bone cement (FBDEAp) exhibited clinically acceptable setting time and injectability.
  • FBDEAp demonstrated good compressive strength (5-7 MPa), resorbability (28% in 12 weeks), and interconnected macroporosity (50-400 μm).
  • Significantly enhanced MG63 cell viability (>125%), adhesion, proliferation, and osteogenic gene expression (5-13 folds) were observed compared to synthetic controls.

Conclusions:

  • The FBDEAp bone cement, derived from natural eggshell and fishbone, possesses favorable physicochemical and mechanical properties.
  • FBDEAp exhibits excellent biocompatibility and osteoinductive potential, promoting cell growth and differentiation.
  • This naturally derived apatite bone cement is a promising candidate for trabecular bone defect repair in orthopedics.