Gold-catalyzed cyclization and cycloaddition in natural product synthesis

Area of Science:

• Organic Chemistry
• Catalysis
• Natural Product Synthesis

Background:

• Transition metal catalysis is crucial for efficient molecular assembly.
• Gold catalysis offers a versatile approach for creating complex structures.
• Natural product synthesis relies on innovative synthetic methodologies.

Purpose of the Study:

• To review the application of homogeneous gold catalysis in the ring-forming step of natural product total synthesis.
• To highlight key advancements in gold-catalyzed reactions from 2016 to mid-2023.
• To categorize synthetic strategies based on the types of ring formations achieved.

Main Methods:

• Literature review of publications from 2016 to mid-2023.
• Focus on total synthesis of natural products utilizing gold catalysis.
• Categorization of reactions by ring formation type.

Main Results:

• Identified diverse applications of gold catalysis in constructing natural products.
• Showcased gold-catalyzed methodologies for challenging ring formations.
• Demonstrated the efficiency of gold catalysis in streamlining synthetic routes.

Conclusions:

• Homogeneous gold catalysis is a powerful tool for natural product synthesis.
• Gold-catalyzed ring formations provide robust pathways to complex molecular architectures.
• This review underscores the growing importance and versatility of gold catalysis in synthetic chemistry.