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Regulatory RNAs in immunosenescence
Atefe Ghamar Talepoor1,2, Mehrnoosh Doroudchi1
1Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Immunity, Inflammation and Disease
|March 8, 2024
Summary
Regulatory RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), play a crucial role in immunosenescence. These noncoding RNAs (ncRNAs) regulate immune cell function and inflammation during aging.
Area of Science:
- Immunology
- Molecular Biology
- Aging Research
Background:
- Immunosenescence involves immune system deterioration due to various stressors.
- Genomic and epigenomic changes accompany immunosenescence.
- Noncoding RNAs (ncRNAs) are increasingly recognized as regulators of immunosenescence.
Purpose of the Study:
- To review the regulatory roles of ncRNAs in immunosenescence.
- To evaluate the impact of miRNAs, lncRNAs, and circRNAs on immune aging.
Main Methods:
- Systematic analysis of publications on regulatory RNAs and immunosenescence.
- Focus on diverse aspects of immunosenescence influenced by ncRNAs.
Main Results:
- ncRNAs regulate immunosenescence at transcriptional and post-transcriptional levels.
- These ncRNAs control gene expression, senescence phenotype, and inflammation.
- Specific ncRNAs like miRNAs, lncRNAs, and circRNAs are key players.
Conclusions:
- Regulatory RNAs are central to the complex process of immunosenescence.
- Understanding ncRNA function in immune cells enhances knowledge of aging.
- ncRNAs offer potential targets for interventions in age-related immune decline.
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