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Updated: Jul 1, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Directing-Group-Assisted Non-Strained Ether C-O Bond Homolysis Mediated by Low-Valent Titanium
Takuya Suga1, Ryusei Takada1, Masaya Sakamoto1
1Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University,, Kakuma, Kanazawa, 920-1192, Japan.
Abstract:
Ether C-O bonds are typical constituents of organic molecules that are seldom regarded as reactive functional groups except when highly strained. With the assistance of appropriate directing groups, low-valent titanium was found to homolytically cleave non-strained C-O bonds. In particular, a newly designed catechol monoether directing group rendered a route toward the activation of non-benzylic C(sp3)-O bonds. This method has been applied to conventional radical addition reactions to alkenes.
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