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Cutaneous Hydrophilic Polymer Embolism: An Important and Overlooked Clinical Entity
Kimberly Pei Rui Chan1, Joyce Siong See Lee1,2, Joel Hua Liang Lim1
1National Skin Center, Singapore, Singapore ; and.
The American Journal of Dermatopathology
|March 8, 2024
Summary
Hydrophilic polymer embolism from medical devices can cause organ damage and death. This study highlights its features to increase awareness of this iatrogenic condition.
Area of Science:
- Medical Devices
- Pathology
- Vascular Medicine
Background:
- Hydrophilic polymer embolism is an underrecognized complication of vascular medical devices.
- Minimally invasive procedures are increasingly common, raising concerns about iatrogenic complications.
Purpose of the Study:
- To underscore the clinicopathological features of cutaneous hydrophilic polymer embolism.
- To increase awareness of this iatrogenic entity.
Main Methods:
- Retrospective analysis of histopathological tissue samples.
- Detailed case study of two patients with cutaneous hydrophilic polymer embolism.
Main Results:
- Histopathological findings include endoluminal, cerebriform, amorphous, anucleate, basophilic, nonrefractile, nonpolarizable foreign body material.
- Two additional cases of cutaneous hydrophilic polymer embolism are presented.
Conclusions:
- Hydrophilic polymer embolism is a significant iatrogenic cause of end-organ ischemia and mortality.
- Increased clinical awareness and prompt diagnosis are crucial for managing this condition.
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