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Updated: May 2, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
Published on: June 2, 2015
Remote Ischemic Conditioning With Medical Management or Reperfusion Therapy for Acute Ischemic Stroke: A Systematic
Qi Li1, Jinxiu Guo1, Hui-Sheng Chen1
1From the Department of Neurology (Q.L., X.F., B.J., B.L., M.Y., Z.Q., Y.D.), The 903rd Hospital of The Chinese People's Liberation Army, Hangzhou; Intensive Care Unit of Department of Neurology (J.G.), Ningbo Medical Center Lihuili Hospital; Department of Neurology (H.-S.C.), General Hospital of Northern Theater Command, Shenyang, China; Department of Neurology (R.A.B.), Aarhus University Hospital, Denmark; Department of Neurology (D.C.H.), Medical College of Georgia, Augusta University, Augusta; Neurology and Stroke Center (F.P.), Versailles Mignot Hospital, Paris, France; Department of Neurology (P.K.), University of Cincinnati, OH; Department of Medicine and Neurology (B.C.V.C.), Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Boston Medical Center (M.A., T.N.N.), Boston University Chobanian and Avedisian School of Medicine, MA; Department of Neurology (J.L.S.), University of California in Los Angeles; Department of Neurology and Neurosurgery (R.G.N.), University of Pittsburgh Medical Center, PA; Department of Neurology (H.S.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou; and Department of Neurology (Q.Y.), Xinqiao Hospital of Army Medical University, Chongqing, China.
Remote ischemic conditioning (RIC) did not improve functional outcomes for stroke patients but reduced stroke recurrence and improved NIHSS scores in those not receiving reperfusion therapy. RIC showed no benefit for patients undergoing IVT or MT.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Regenerative Medicine
Background:
- Remote ischemic conditioning (RIC) is a promising neuroprotective strategy for acute ischemic stroke.
- Its efficacy and safety remain controversial, necessitating further investigation into specific patient populations.
Conclusions:
- RIC is not beneficial for functional outcomes (mRS) in ischemic stroke patients.
- RIC significantly improves NIHSS scores and reduces stroke recurrence in patients not eligible for reperfusion therapy.
- RIC offers no observed benefit for patients receiving intravenous thrombolysis (IVT) or mechanical thrombectomy (MT).
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