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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Documentation of Nursing Diagnosis01:10

Documentation of Nursing Diagnosis

The nurse documents nursing diagnoses and enters them into the patient record. The identified patient's nursing diagnosis is either written out with a plan of care or entered into the electronic health record.
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters assessment...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

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Related Experiment Video

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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
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Synovial sarcoma: the misdiagnosed sarcoma.

Chengxiang Li1,2, Fatime Krasniqi3,4, Ricardo Donners4,5

  • 1Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland.

EFORT Open Reviews
|March 8, 2024
PubMed
Summary

Synovial sarcoma, a rare cancer, is often misdiagnosed due to subtle symptoms. Early detection via SS18 gene rearrangement testing and prompt treatment are crucial for better outcomes.

Keywords:
malignantmisdiagnosedsarcomasynovial sarcoma

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Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • Synovial sarcoma (SS) is a rare, highly malignant soft tissue sarcoma.
  • Its early symptoms are often inconspicuous and diverse, leading to frequent misdiagnosis.
  • Challenging management and poor prognosis underscore the need for early diagnosis and treatment.

Purpose of the Study:

  • To review synovial sarcoma (SS) focusing on clinical presentation, diagnosis, and treatment.
  • To highlight the importance of early and accurate diagnosis for patient outcomes.
  • To discuss the role of SS18 gene rearrangement in diagnosing SS.

Main Methods:

  • Review of clinical and radiological presentation.
  • Histological and cytogenetic analysis, including SS18 gene rearrangement detection.
  • Evaluation of treatment modalities: surgery, radiotherapy, and chemotherapy.

Main Results:

  • SS18 gene rearrangement is a key diagnostic marker for synovial sarcoma.
  • Biopsies and gene rearrangement testing are recommended when SS is suspected.
  • Treatment strategies depend on tumor size, margins, and disease stage.

Conclusions:

  • Early and correct diagnosis, particularly through SS18 gene rearrangement testing, is critical.
  • Multimodal treatment including surgery, radiotherapy, and chemotherapy is essential.
  • Timely intervention significantly impacts the prognosis of synovial sarcoma.