Prostatic stromal tumour of uncertain malignant potential in a dog

Tomokazu Nagashima ¹, Masanori Kobayashi ², Yoshiaki Kubo ³

⁰Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo, 180-8602, Japan.

Journal of Comparative Pathology +

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March 8, 2024

View abstract on PubMed

Summary

A prostatic stromal tumor of uncertain malignant potential was diagnosed in a Miniature Dachshund presenting with dyschezia. Surgical removal was performed, and the tumor showed atypical stromal cells with specific immunohistochemical markers.

Area Of Science

Veterinary Pathology
Canine Oncology
Surgical Oncology

Background

Dyschezia in dogs can indicate various underlying conditions, including prostatic diseases.
Prostatic tumors, though less common than other canine neoplasms, require accurate diagnosis and characterization.

Observation

An 11-year-old Miniature Dachshund presented with dyschezia, leading to the discovery of a significant prostate mass via computed tomography.
Surgical intervention, including prostatectomy and orchiectomy, was performed. Gross examination revealed a demarcated, rubbery, whitish mass.
Microscopic analysis showed a capsulated tumor with atypical spindloid stromal cells in phyllode and fasciculated patterns, admixed with ductal cells.

Findings

Immunohistochemical analysis of the atypical stromal cells revealed positivity for vimentin, CD34, desmin, alpha-smooth muscle actin, progesterone receptor, and androgen receptor.
The stromal cells were negative for cytokeratin AE1/AE3, p63, c-Kit, DOG-1, and SOX10.
The combination of morphological and immunohistochemical features led to the diagnosis of a prostatic stromal tumor of uncertain malignant potential.

Implications

This case highlights the importance of comprehensive diagnostic approaches, including advanced imaging and immunohistochemistry, for accurate characterization of canine prostatic tumors.
The diagnosis of 'uncertain malignant potential' underscores the need for careful monitoring and further research into the behavior and prognosis of such tumors in dogs.
Understanding the specific immunohistochemical profile aids in differentiating prostatic stromal tumors from other prostatic neoplasms and informs potential therapeutic strategies.

Keywords:

dog mesenchymal tumour prostate stromal tumour of uncertain malignant potential