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Higher Risk of Psychiatric Disorders in Children With Febrile Seizures: A Nationwide Cohort Study in Taiwan

Der-Shiun Wang1, Chi-Hsiang Chung2, Wan-Fu Hsu3

  • 1Department of Pediatrics, School of Medicine, National Defense Medical Center, Taipei, Taiwan; Department of Pediatrics, Tri-Service General Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Pediatric Neurology
|March 8, 2024
PubMed

Insights

Children experiencing febrile seizures have a significantly higher risk of developing psychiatric disorders, particularly anxiety. Early attention to mental health symptoms in these children is recommended.

Area of Science:

  • Pediatrics
  • Child Psychiatry
  • Epidemiology

Background:

  • Febrile seizures are common in young children (6 months to 6 years).
  • Previous research suggests a link between febrile seizures and psychiatric disorders.
  • This study investigates this association in Taiwan.

Purpose of the Study:

  • To examine the association between febrile seizures and psychiatric disorders in children.
  • To identify risk factors associated with psychiatric disorders following febrile seizures.

Main Methods:

  • Population-based nationwide observational cohort study using Taiwan's National Health Insurance Research Database (2000-2015).
  • Included 2464 children with febrile seizures and 7392 matched controls.
  • Follow-up time averaged 11.04 years.

Main Results:

  • Children with febrile seizures showed a 4.70-fold increased risk of psychiatric disorders (aHR, 4.70; 95% CI, 2.44-7.30).
  • The risk for anxiety was notably high (aHR, 21.92; 95% CI, 11.40-34.05).

Conclusions:

  • Children with febrile seizures require careful monitoring for psychiatric disorder symptoms.
  • Early referral for mental health assessment may benefit children with a history of febrile seizures.
Abstract

Keywords:
Febrile seizuresNational databasePediatricPsychiatric disorders

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